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Serotonin-[d4] Hydrochloride

General Information
Catalog: BLP-004222
Molecular Formula: C10H9D4ClN2O
Molecular Weight: 216.68
Chemical Structure
Serotonin-[d4] Hydrochloride
Description Serotonin-[d4] Hydrochloride is a labelled form of Serotonin HCl. Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
Synonyms Hippophaine-d4 Hydrochloride; 5-HT-d4; 5-Hydroxytryptamine-d4
IUPAC Name 3-(2-amino-1,1,2,2-tetradeuterioethyl)-1H-indol-5-ol;hydrochloride
Related CAS 153-98-0 (unlabelled) 58264-95-2 (free base)
Canonical SMILES C1=CC2=C(C=C1O)C(=CN2)CCN.Cl
InChI InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H/i3D2,4D2;
InChI Key MDIGAZPGKJFIAH-URZLSVTISA-N
Melting Point 127-132°C(dec.)
Purity ≥90%
Solubility Soluble in Methanol, Water
Storage Store at 2-8°C

Serotonin-[d4] Hydrochloride, a stable isotope-labeled compound utilized in diverse bioscience applications, has multifaceted roles. Here are key applications of Serotonin-[d4] Hydrochloride showcased with elevated perplexity and burstiness:

Pharmacokinetics and Drug Metabolism: Delving into pharmacokinetic realms, Serotonin-[d4] Hydrochloride emerges as an essential internal standard for precisely gauging the metabolism and clearance of serotonin itself. This scientific tool enables researchers to track serotonin levels in biological specimens, unraveling its involvement in physiological and pharmacological processes. Such insights are pivotal in assessing the effectiveness and safety of medications targeting the intricate serotonin system.

Neuropsychiatric Research: In the intricate domain of neuropsychiatric exploration, Serotonin-[d4] Hydrochloride assumes a pivotal role in untangling the complexities of serotonin in disorders like depression and anxiety. By tracing labeled serotonin in animal models, researchers navigate its distribution and functions across diverse brain regions. This pivotal investigation aids in deciphering the mechanisms underpinning serotonin-related disorders and in formulating potential therapeutic strategies.

Mass Spectrometry: Within the analytical chemistry realm, Serotonin-[d4] Hydrochloride finds significance in mass spectrometry for quantitatively analyzing serotonin levels within complex biological matrices. With its distinctively labeled structure, it enables precise differentiation from endogenous serotonin, heightening measurement accuracy. This application is indispensable in both basic research and clinical diagnostics, aiding in evaluating serotonin balance and associated health conditions with enhanced precision.

Drug Interaction Studies: Researchers harness Serotonin-[d4] Hydrochloride for probing intricate drug interactions involving the serotonin pathway. By integrating it into experimental setups, scientists dissect how novel drug candidates impact serotonin metabolism and receptor activity. This critical data is fundamental for anticipating potential side effects and refining therapeutic strategies involving serotonergic medications.

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