Name: Urapidil-[d3] (methoxy-[d3])
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-013917

CAS: 1398066-08-4

Molecular Formula: C20H26D3N5O3

Molecular Weight: 390.49

Chemical Structure

Description	An isotope labelled of Urapidil .Urapidil is an α1-adrenoceptor antagonist and as an 5-HT1A receptoragonist. It is a sympatholytic antihypertensive drug.
Synonyms	6-[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethyluracil
Related CAS	34661-75-1 (unlabelled) 64887-14-5 (unlabelled hydrochloride)
Canonical SMILES	CN(C(NCCCN(CC1)CCN1C2=CC=CC=C2OC([2H])([2H])[2H])=CC(N3C)=O)C3=O
InChI	InChI=1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3/i3D3
InChI Key	ICMGLRUYEQNHPF-HPRDVNIFSA-N
Purity	98% by HPLC; 99% atom D

Urapidil-[d3] (methoxy-[d3]), a deuterated analog of urapidil, serves as a valuable research tool in various scientific investigations. Here are the key applications of Urapidil-[d3] (methoxy-[d3]):

Pharmacokinetic Studies: In the realm of pharmacokinetic research, Urapidil-[d3] (methoxy-[d3]) plays a pivotal role in scrutinizing the drug’s absorption, distribution, metabolism, and excretion. The incorporation of deuterium labeling enables precise tracking within biological systems, offering intricate insights into the drug’s behavioral patterns. This detailed information aids in fine-tuning drug formulations and enhancing therapeutic effectiveness.

Metabolomic Profiling: Researchers delve into metabolomic studies using Urapidil-[d3] (methoxy-[d3]) to unravel the impact of urapidil on metabolic pathways. By juxtaposing the deuterated variant with its non-labeled counterpart, scientists can pinpoint and quantify metabolites with exceptional precision. This approach aids in unraveling drug mechanisms and potential metabolic ramifications, shedding light on intricate biological processes.

Mass Spectrometry Calibration: Acting as an internal standard in mass spectrometry analyses, Urapidil-[d3] (methoxy-[d3]) facilitates the accurate quantification of urapidil in complex biological samples. The deuterated compound aids in rectifying matrix effects and variability in instrument responses, thereby boosting the reliability of analytical measurements in pharmacological and clinical inquiries.

Receptor Binding Studies: The deuterated iteration of urapidil finds its niche in receptor binding assays, unraveling its interactions with adrenergic receptors with unparalleled precision. By leveraging Urapidil-[d3] (methoxy-[d3]), researchers can differentiate between the parent compound and its metabolites, offering crucial insights into binding affinity, receptor selectivity, and pharmacodynamics of the drug. This knowledge fuels the development of more potent and efficacious therapeutic interventions.