Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
BOC Sciences has many years of industry experience, comprehensive analysis capabilities, complete instruments and a strong team to provide isotope analysis services. Our behavior is efficient, the method is scientific, the data is rigorous, the service is efficient, and we can answer industry questions for customers.
Stable isotope ratio mass spectrometry is the study of natural and synthetic samples based on isotope ratios. The isotopic ratios of a sample will vary due to its source and origin and the processes that may occur during the life of that material. Stable isotope ratio mass spectrometry is widely used in different research fields such as geology, ecology, environment, medicine, pharmaceuticals, agriculture, atmospheric science, material science, and food. We provide a comprehensive isotope ratio mass spectrometry solution, including hydrogen, carbon, oxygen, nitrogen, sulfur isotope ratio mass spectrometry, to meet customer analysis needs.
Isotopic mass spectrometry determines the elemental composition of molecules based on high-resolution mass spectra with resolved isotopic peaks. Isotopic mass spectrometry is widely used in agriculture, medicine, environmental science, oceanography, petroleum, chemical industry, metallurgy, etc. The advanced instrumentation portfolio includes a small low-resolution isotopic mass spectrometer for isotopic analysis of light elements (hydrogen, carbon, sulfur) and a large-scale isotopic mass spectrometer with higher resolution for isotopic analysis of heavy elements (uranium, plutonium, lead).
Elemental analysis techniques can simultaneously or individually analyze several elements in a sample. Our isotope element analysis platform is mainly for chemical composition analysis and isotope analysis of samples such as rock ore, plants, soil, etc., to realize the element determination of samples. We usually combine elemental analysis with isotopic mass spectrometry to achieve the determination of carbon and nitrogen isotopes in samples such as plants and soil. Cooperate with standard samples and methods, while performing isotope determination, obtain the content of the response element of the sample.
Isotope chromatography involves general methods of research experiments and analysis in chemistry, food, medicine, geology, etc. Because isotopes have the same chemical properties, their analysis can only be achieved by exploiting small differences in their physical properties. Gas chromatography and liquid chromatography can be used for isotope separation and analysis of hydrogen, nitrogen, oxygen, etc.
The stable isotope dilution method can use stable isotope-labeled compounds as internal standards to quantitatively determine the content of non-labeled compounds, which improves the accuracy of the determination results and the stability of the analysis method. This method has the advantages of high sensitivity, no need for quantitative separation of the analyte, effective offset of matrix influence and pretreatment operation loss, etc., and is suitable for the analysis of samples with complex components and difficult separation. This method is widely used in quantitative analysis of biomarkers, drugs and their metabolites.
Fig. 1 The content calculation formula of isotope dilution method
NMR is an important method for stable isotope analysis. NMR can detect isotopes on different groups in organic samples. According to the peak height of the spectrum, the content of the isotope can also be determined.
Deuterium content in hydrogen compounds can be determined by using the spectral line shift caused by isotope substitution in infrared vibrational spectroscopy. Atomic absorption, emission spectroscopy, etc. can be used for nitrogen isotope analysis.