Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
BOC Sciences is committed to providing high quality analytical services for chemical purity. Our analytical laboratory has advanced instruments, a strong team, and strictly controls the experimental details to provide customers with scientific solutions and strong technical support.
In the development and analysis of stable isotope-labeled reagents, chemical purity is a very important indicator. Chemical purity analysis is generally performed by gas chromatography or liquid chromatography. The chromatographic retention behavior of stable isotope-labeled compounds and naturally-abundant unlabeled compounds is consistent, often at the same retention time. Therefore, the purity of labeled compounds is usually analyzed using standards of natural abundance.
|Sample types||Service items|
|13C urea and its kit||Chemical purity|
|13C labeling reagents||Chemical purity|
|15N labeling reagents||Chemical purity|
|18O labeling reagents||Chemical purity|
|2H (D) labeling reagents||Chemical purity|
Among them, Csample is the purity of the sample; Cstandard is the purity of the standard substance; Asample is the peak area of the sample; Astandard is the peak area of the standard substance; r is the relative molecular mass correction coefficient.
Using high-performance liquid chromatography and external standard method, a standard curve was established, and a chemical purity analysis method for stable isotope-labeled samples was established. The specific process is to use the HPLC method to analyze a series of standard solutions with gradient concentrations, draw a standard curve, and obtain the corresponding relational formula. Using the external standard method, the chemical purity of the sample was calculated according to the formula.
The stable isotope-labeled compound is used as a sample for chemical purity analysis, and the peak area of the ion flow diagram is obtained by using a gas chromatograph, thereby realizing the determination of chemical purity. The specific process is to prepare a series of standard solutions of unlabeled compounds with concentration gradients, use GC to analyze, plot the concentration versus peak area, draw a standard curve, and finally calculate the chemical purity of the sample according to the formula.
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