Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
BOC Sciences can provide various isotope abundance detection services for global customers. As a company with efficient management, first-class technology, comprehensive service and customer trust, we have long been committed to promoting the rapid development of the isotope analysis and testing industry.
Atoms with the same number of protons have different masses due to the number of neutrons contained in the nucleus, and these atoms are called isotopes. Having too many or too few neutrons compared to protons can lead to isotopic instability. These unstable radioactive isotopes will decay into stable isotopes. Due to the unique stable combination of protons and neutrons, isotopes that do not decay are stable isotopes. The relative amounts of various isotopes of an element present in nature are called isotopic abundances. Isotopic abundance determination has important applications in geology, chemistry, biology, medicine and other fields.
|Sample types||Service items|
|13C urea||13C isotopic abundance determination|
|13C labeling reagents||13C isotopic abundance determination|
|15N labeling reagents||15N isotopic abundance determination|
|18O labeling reagents||18O isotopic abundance determination|
|2H (D) labeling reagents||2H (D) isotopic abundance determination|
|Plant||Isotopic abundance determination|
|Soil||Isotopic abundance determination|
|Water||Isotopic abundance determination|
|Gas||Isotopic abundance determination|
When determining the natural abundance of stable isotopes, it is generally expressed by the δ value, and the unit is the difference per thousand (‰, per mill). It is the per-thousandth deviation of the isotope ratio of the analyzed sample relative to the laboratory reference material (working standard), and then convert this value into the δ value relative to the international isotope standard.
Among them, Rsample: the isotope ratio of the sample; Rstandard: the isotope ratio of the laboratory reference material (working standard)
δ > 0, indicating that the sample is enriched in heavy isotopes relative to the standard
δ < 0, indicating that the sample is depleted of heavy isotopes relative to the standard
δ = 0, indicating that the sample has the same isotope ratio as the standard
In the stable isotope tracer experiment, the isotope abundance expressed in atomic percent is used. This is an absolute measurement of the number of atoms of a particular isotope contained in 100 atoms of an element. For example, the element carbon (C) has two stable isotopic forms, 12C and 13C. The percentage of 13C atoms in the total carbon atoms (12C +13C) is the atomic percentage of 13C (13C atom%), also known as the abundance of 13C.