2-Amino-2-deoxy-D-glucose-[2-13C] hydrochloride

2-amino-2-deoxy-D-glucose-[2-13C] hydrochloride is a stable isotope-labeled glucose analog used for a variety of applications in biochemical and preclinical research. Here are some key applications:

Metabolic Flux Analysis: This compound is used in metabolic flux analysis to track glucose utilization and metabolism within cells. By incorporating the labeled glucose into metabolic pathways, researchers can quantify fluxes through glycolysis and other pathways. This helps in understanding cellular energy production, metabolic reprogramming in diseases, and the effects of pharmacological interventions.

Cancer Research: 2-amino-2-deoxy-D-glucose-[2-13C] hydrochloride is utilized in cancer research to study tumor metabolism. Cancer cells often exhibit altered glucose metabolism, known as the Warburg effect, which can be monitored using this labeled glucose analog. This information can assist in identifying abnormal metabolic pathways and potential therapeutic targets in oncology.

Neuroimaging: In neuroimaging studies, this compound is used in conjunction with techniques such as Magnetic Resonance Spectroscopy (MRS) to visualize and measure brain metabolism. It allows researchers to investigate glucose uptake and utilization in various brain regions under different physiological and pathological conditions. This is particularly valuable in studying conditions like Alzheimer's disease and other neurological disorders.

Pharmacokinetics: 2-amino-2-deoxy-D-glucose-[2-13C] hydrochloride can be used to study the pharmacokinetics and bioavailability of drugs that influence glucose metabolism. By tracking the labeled glucose in vivo, researchers can evaluate how drugs affect glucose uptake, distribution, and utilization. This can provide insights into drug efficacy and safety, as well as metabolic side effects.