2-deoxy-2-fluoro-D-glucose-[UL-13C6]-6-phosphate dipotassium salt

2-deoxy-2-fluoro-D-glucose-[UL-13C6]-6-phosphate dipotassium salt, a specialized glucose analog, finds diverse applications in biochemical and medical research. Here are the key applications:

Cancer Research: Delving into the realm of cancer research, this compound serves as a pivotal tool for scrutinizing glucose metabolism within tumor cells. By integrating it into metabolic assays, researchers can meticulously track the uptake and utilization of glucose in cancerous cells, thereby shedding light on tumor metabolism. This invaluable data underpins the development of targeted therapies aimed at disrupting the metabolic pathways crucial for tumor proliferation.

Positron Emission Tomography (PET) Imaging: Embracing the world of medical imaging, 2-deoxy-2-fluoro-D-glucose derivatives like this hold paramount importance in PET imaging for diagnosing and monitoring various diseases, notably cancer. By employing this labeled glucose analog, experts can visualize metabolic activity in tissues, enabling early disease detection and facilitating treatment strategizing. This modality offers intricate insights into tissue function and disease evolution, aiding in precision healthcare interventions.

Glycolytic Pathway Studies: Acting as a cornerstone in glycolytic pathway research, this glucose analog engages in fierce competition with endogenous glucose, undergoing phosphorylation but halting further metabolism. Researchers harness this distinctive property to unravel cellular mechanisms governing glycolysis and to decipher how deviations in this pathway contribute to disease pathogenesis. This application is particularly instrumental in dissecting metabolic anomalies observed in diseases such as diabetes and cancer.

Enzyme Kinetics: Unleashing its potential in enzyme kinetics investigations, 2-deoxy-2-fluoro-D-glucose-[UL-13C6]-6-phosphate dipotassium salt serves as a key player in studying the behaviors of glycolysis-associated enzymes like hexokinase. By dissecting the intricate interactions between this analog and specific enzymes, scientists can unravel crucial insights into enzyme activity, specificity, and regulation. These meticulous studies form the bedrock for understanding enzyme functionalities and for crafting inhibitors capable of modulating enzyme activities for therapeutic advancements.