2'-Deoxy-L-uridine-[13C,15N2]

2'-Deoxy-L-uridine-[13C,15N2] stands out as a stable isotope-labeled nucleoside with diverse research applications. Explore its versatile uses through these high perplexity and burstiness descriptions:

Metabolic Flux Analysis: Delve into the intricate world of metabolic studies with 2'-Deoxy-L-uridine-[13C,15N2], a key player in tracing nucleotide metabolism pathways using stable isotope markers. Witness researchers monitoring the incorporation of this labeled nucleoside into DNA, unraveling the dynamic nature of nucleotide pools within cells. This insight into metabolic alterations in disease states and the optimization of interventions opens new frontiers in cellular understanding.

Genetic and Genomic Research: Embark on a genetic odyssey with 2'-Deoxy-L-uridine-[13C,15N2], illuminating the realms of DNA replication and repair processes in living cells. By integrating this compound into DNA, scientists showcase their ability to discern newly synthesized strands from pre-existing DNA structures. This critical technique underpins investigations into genomic stability, nucleotide excision repair mechanisms, and the orchestration of cell cycle progression.

Cancer Research: Unveiling a profound impact on oncology, 2'-Deoxy-L-uridine-[13C,15N2] emerges as a cornerstone for dissecting tumor growth dynamics and therapeutic responses. Witness the meticulous tracking of labeled nucleoside integration into tumor DNA, enabling researchers to gauge cell proliferation rates with precision. These revelations offer deep insights into the efficacy of anticancer therapies and the varying aggressiveness exhibited across different cancer subtypes.

Pharmacokinetic Studies: Explore the realm of drug dynamics with this isotopically labeled nucleoside, a beacon guiding pharmacokinetic studies of nucleoside analog drugs. Trace its journey through absorption, distribution, metabolism, and excretion pathways, unlocking vital data on drug behavior within the human body. This pivotal research aids in refining drug development strategies, optimizing dosing regimens, and enhancing the outcomes of therapeutic interventions.