3-O-Methyl-D-glucose-[13C6]

3-O-Methyl-D-glucose-[13C6], a carbon-13 labeled glucose analog, finds widespread use in metabolic studies and diverse research applications. Here are the key applications:

Metabolic Flux Analysis: Delving into cellular metabolism, researchers employ 3-O-Methyl-D-glucose-[13C6] in metabolic flux analysis to trace the intricate pathways of glucose metabolism. By monitoring the incorporation of this labeled glucose, scientists unravel key metabolic routes and decipher how diverse conditions (such as drugs or mutations) impact cellular metabolism. This investigative approach is indispensable for unearthing novel therapeutic targets and fine-tuning metabolic pathways in the realm of biotechnology.

Glucose Transport Studies: Unveiling the mysteries of glucose transport mechanisms across cell membranes, this labeled glucose analog serves as a powerful tool. Researchers quantify the rate of glucose uptake and assess the efficiency of various glucose transporters in distinct cell types. These insights play a pivotal role in comprehending diseases like diabetes, characterized by impaired glucose transport, shedding light on potential avenues for therapeutic intervention.

NMR Spectroscopy: Embracing nuclear magnetic resonance (NMR) spectroscopy, scientists leverage 3-O-Methyl-D-glucose-[13C6] to analyze metabolic products with precision. The carbon-13 labeling affords detailed spectral analysis, enabling real-time monitoring of specific metabolites. This cutting-edge technology enables the generation of comprehensive metabolic profiles, enriching our understanding of intracellular biochemical processes and facilitating advancements in metabolic research.

Cancer Research: In the domain of cancer research, 3-O-Methyl-D-glucose-[13C6] emerges as a valuable asset for exploring the altered metabolic landscapes of cancer cells. Exhibiting heightened glucose uptake and glycolysis, a phenomenon known as the Warburg effect, cancer cells provide fertile ground for investigation using this labeled glucose analog. By scrutinizing these metabolic alterations, researchers glean insights into tumor biology and unearth potential metabolic vulnerabilities ripe for exploitation in targeted therapies.