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6-Methyleneandrost-4-ene-3,17-dione-[d3]

General Information
Catalog: BLP-007857
Molecular Formula: C20H23D3O2
Molecular Weight: 301.44
Chemical Structure
6-Methyleneandrost-4-ene-3,17-dione-[d3]
Description 6-Methyleneandrost-4-ene-3,17-dione-[d3] is the labelled analogue of 6-Methyleneandrost-4-ene-3,17-dione, which is a metabolite of Exemestane. Exemestane is a third generation, irreversible steroidal aromatase inhibitor.
Synonyms 6-Methyleneandrost-4-ene-3,17-dione-19-d3; Exemestane Related Compound A-D3; 1,2-Dihydro Exemestane-d3
IUPAC Name (8R,9S,10R,13S,14S)-13-methyl-6-methylidene-10-(trideuteriomethyl)-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione
Related CAS 19457-55-7 (unlabelled)
Canonical SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)CCC34C
InChI InChI=1S/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h11,14-16H,1,4-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1/i2D3
InChI Key KQRGETZTRARSMA-OAXLLPIKSA-N
Melting Point 149-152°C
Purity 98%
Solubility Soluble in Chloroform
Appearance Off-white to Dark Yellow Solid
Storage Store at 2-8°C

6-Methyleneandrost-4-ene-3,17-dione-[d3], a deuterated steroid utilized in diverse scientific and clinical research endeavors, plays a pivotal role in investigating steroid metabolism and distribution in the body. By leveraging its deuterated properties, researchers delve into the absorption, distribution, metabolism, and excretion (ADME) processes of steroids, unraveling crucial insights into pharmacokinetics.

Endocrine Research finds a valuable ally in 6-Methyleneandrost-4-ene-3,17-dione-[d3], enabling detailed exploration of steroid hormone functions and their physiological impacts. Serving as a potent investigative tool, it elucidates interactions between steroids and their receptors, shedding light on downstream biological effects and fostering a deeper understanding of steroid hormone implications in health and disease dynamics.

The realm of Isotope Dilution Mass Spectrometry relies on 6-Methyleneandrost-4-ene-3,17-dione-[d3] as an internal standard to ensure unparalleled precision in quantitative analyses of steroid levels in biological specimens. This methodological approach, instrumental in clinical diagnostics and research, furnishes steadfast data for hormone concentration measurements, aiding in the detection and monitoring of hormone imbalances in various medical conditions.

Biochemical Assays harness the power of 6-Methyleneandrost-4-ene-3,17-dione-[d3] to delve into enzyme activity associated with steroid synthesis and metabolism. Employing this deuterated steroid as a substrate or inhibitor, researchers dissect enzyme kinetics and regulatory mechanisms, deepening insights into steroid biosynthesis pathways and paving the way for potential therapeutic interventions in related disorders.

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