Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-007857 |
Molecular Formula: C20H23D3O2 |
Molecular Weight: 301.44 |
Chemical Structure |
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Description | 6-Methyleneandrost-4-ene-3,17-dione-[d3] is the labelled analogue of 6-Methyleneandrost-4-ene-3,17-dione, which is a metabolite of Exemestane. Exemestane is a third generation, irreversible steroidal aromatase inhibitor. |
Synonyms | 6-Methyleneandrost-4-ene-3,17-dione-19-d3; Exemestane Related Compound A-D3; 1,2-Dihydro Exemestane-d3 |
IUPAC Name | (8R,9S,10R,13S,14S)-13-methyl-6-methylidene-10-(trideuteriomethyl)-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione |
Related CAS | 19457-55-7 (unlabelled) |
Canonical SMILES | CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)CCC34C |
InChI | InChI=1S/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h11,14-16H,1,4-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1/i2D3 |
InChI Key | KQRGETZTRARSMA-OAXLLPIKSA-N |
Melting Point | 149-152°C |
Purity | 98% |
Solubility | Soluble in Chloroform |
Appearance | Off-white to Dark Yellow Solid |
Storage | Store at 2-8°C |
6-Methyleneandrost-4-ene-3,17-dione-[d3], a deuterated steroid utilized in diverse scientific and clinical research endeavors, plays a pivotal role in investigating steroid metabolism and distribution in the body. By leveraging its deuterated properties, researchers delve into the absorption, distribution, metabolism, and excretion (ADME) processes of steroids, unraveling crucial insights into pharmacokinetics.
Endocrine Research finds a valuable ally in 6-Methyleneandrost-4-ene-3,17-dione-[d3], enabling detailed exploration of steroid hormone functions and their physiological impacts. Serving as a potent investigative tool, it elucidates interactions between steroids and their receptors, shedding light on downstream biological effects and fostering a deeper understanding of steroid hormone implications in health and disease dynamics.
The realm of Isotope Dilution Mass Spectrometry relies on 6-Methyleneandrost-4-ene-3,17-dione-[d3] as an internal standard to ensure unparalleled precision in quantitative analyses of steroid levels in biological specimens. This methodological approach, instrumental in clinical diagnostics and research, furnishes steadfast data for hormone concentration measurements, aiding in the detection and monitoring of hormone imbalances in various medical conditions.
Biochemical Assays harness the power of 6-Methyleneandrost-4-ene-3,17-dione-[d3] to delve into enzyme activity associated with steroid synthesis and metabolism. Employing this deuterated steroid as a substrate or inhibitor, researchers dissect enzyme kinetics and regulatory mechanisms, deepening insights into steroid biosynthesis pathways and paving the way for potential therapeutic interventions in related disorders.
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