Name: Amphotericin B Methyl Ester-[13C6]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003309

Molecular Formula: C42[13C]6H75NO17

Molecular Weight: 944.60

Chemical Structure

Description	Labelled analogue of Amphotericin B Methyl Ester which is the methyl ester derivative of the polyene antibiotic Amphotericin B.
Synonyms	methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-n-2-yl]oxy}-1,3,5,6,9,11,17,37,15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
IUPAC Name	methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(1-13C)methyl(2,3,4,5,6-13C5)oxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
Related CAS	36148-89-7 (unlabelled)
Canonical SMILES	CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)OC)OC3C(C(C(C(O3)C)O)N)O
InChI	InChI=1S/C48H75NO17/c1-28-18-16-14-12-10-8-6-7-9-11-13-15-17-19-35(65-47-45(59)42(49)44(58)31(4)64-47)25-39-41(46(60)62-5)38(55)27-48(61,66-39)26-34(52)23-37(54)36(53)21-20-32(50)22-33(51)24-40(56)63-30(3)29(2)43(28)57/h6-19,28-39,41-45,47,50-55,57-59,61H,20-27,49H2,1-5H3/b7-6+,10-8+,11-9+,14-12+,15-13+,18-16+,19-17+/t28-,29-,30-,31+,32+,33+,34-,35-,36+,37+,38-,39-,41+,42-,43+,44+,45-,47-,48+/m0/s1/i4+1,31+1,42+1,44+1,45+1,47+1
InChI Key	UAZIZEMIKKIBCA-QCNQUJJBSA-N

Amphotericin B Methyl Ester-[13C6], a stable isotopically labeled derivative of Amphotericin B, is a valuable tool in research and development. Here are key applications of Amphotericin B Methyl Ester-[13C6], presented with a high degree of perplexity and burstiness.

Isotope Tracing Studies: Employing Amphotericin B Methyl Ester-[13C6], researchers delve into isotope tracing studies to meticulously monitor the distribution and metabolism of Amphotericin B within biological systems. By integrating the stable carbon-13 isotope, scientists can discern labeled molecules from their naturally occurring counterparts. This insight into pharmacokinetics and biodistribution aids in refining antifungal dosing strategies and treatment protocols.

Pharmacokinetic Research: At the forefront of pharmacokinetic investigations, Amphotericin B Methyl Ester-[13C6] facilitates in-depth exploration into the absorption, distribution, metabolism, and excretion (ADME) of the antifungal agent. The utilization of this isotopically enriched form enables precise quantification and analysis within complex biological matrices. Such studies play a pivotal role in unraveling drug behavior within the body and guiding clinical development endeavors.

Analytical Method Development: This compound is a cornerstone in the advancement and validation of analytical methodologies, notably mass spectrometry, for detecting and quantifying Amphotericin B. The isotopic labeling serves as a crucial aid in instrument calibration, ensuring analytical precision and reliability. This meticulous approach to quality control is essential for upholding therapeutic efficacy in pharmaceutical formulations.

Drug Interaction Studies: Expanding the horizon of drug interaction inquiries, Amphotericin B Methyl Ester-[13C6] features prominently in investigations concerning its compatibility with other antifungal or antimicrobial agents. The labeled compound offers a unique opportunity to track its presence and interactions within multi-drug regimens. Insights garnered from these studies can guide efforts to mitigate adverse effects and enhance combined therapeutic strategies, heralding a new era in personalized medicine approaches.