Name: Apixaban-[13C,d7]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003322

Molecular Formula: C24[13C]H18D7N5O4

Molecular Weight: 467.53

Chemical Structure

Description	Isotopic labelled form of Apixaban. Apixaban (INN, trade name Eliquis) is an anticoagulant for the prevention of venous thromboembolism and the prevention of stroke in atrial fibrillation. It is a direct factor Xa inhibitor. Apixaban has been available in Europe since May 2011. The drug was developed in a joint venture by Pfizer and Bristol-Myers Squibb.
Synonyms	1-(4-methoxyphenyl)-7-oxo-6-{4-[2-oxo(2-13C,3,4,4,5,5,6,6-D7)piperidin-1-yl]phenyl}1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
IUPAC Name	6-[4-(2,2,3,3,4,4,5-heptadeuterio-6-oxo(6-13C)azinan-1-yl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
Related CAS	503612-47-3 (unlabelled)
Canonical SMILES	COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
InChI	InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)/i2D2,3D2,4D,14D2,21+1
InChI Key	QNZCBYKSOIHPEH-IJPQQSHYSA-N
Purity	> 98%

Apixaban-[13C,d7] is an isotopically labeled version of the anticoagulant drug Apixaban, used primarily in research settings. Here are some key applications of Apixaban-[13C,d7]:

Pharmacokinetic Studies: Apixaban-[13C,d7] is employed in pharmacokinetic studies to trace the absorption, distribution, metabolism, and excretion of Apixaban in the body. The isotopic labeling allows for precise tracking and quantification using techniques like mass spectrometry. This helps in understanding the drug's behavior in biological systems, which is crucial for optimizing dosing regimens.

Metabolism Research: Researchers use Apixaban-[13C,d7] to study the metabolic pathways and the interaction of the drug with various enzymes. The stable isotope labeling aids in identifying and quantifying metabolites, thereby shedding light on the drug's biotransformation process. Such insights are essential for assessing the drug's efficacy and safety profile.

Drug-Drug Interaction Studies: Utilizing Apixaban-[13C,d7] helps in evaluating potential drug-drug interactions by providing a reliable method to distinguish it from co-administered drugs. By examining how Apixaban-[13C,d7] interacts with other medications, researchers can predict adverse interactions and optimize therapeutic combinations.

Analytical Method Development: Apixaban-[13C,d7] is instrumental in developing and validating analytical methods for drug monitoring in biological samples. Its distinct isotopic signature serves as an internal standard for calibrating instruments and ensuring accuracy in quantitative analyses. This supports regulatory compliance and the development of robust analytical procedures in clinical and research laboratories.