Name: Apomorphine Glucuronide-[d5]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003325

Molecular Formula: C23H20D5NO8

Molecular Weight: 448.48

Chemical Structure

Description	Apomorphine Glucuronide-[d5] is an isotope compound of Apomorphine Glucuronide, a derivative of Apomorphine.
Synonyms	(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((R)-11-hydroxy-1,2,3,6,8,9-D5-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid; (R)-ApoMorphine β-D-Glucuronide D5; (6aR)-5,6,6a,7-Tetrahydro-6-Methyl-4H-dibenzo[de,g]quinoline-10,11-diol 10-β-D-Glucuronide D5
IUPAC Name	(2S,3S,4S,5R,6S)-6-[[(6aR)-1,2,3,8,9-pentadeuterio-11-hydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Canonical SMILES	CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)OC5C(C(C(C(O5)C(=O)O)O)O)O)O
InChI	InChI=1S/C23H25NO8/c1-24-8-7-10-3-2-4-12-15(10)13(24)9-11-5-6-14(17(25)16(11)12)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h2-6,13,18-21,23,25-28H,7-9H2,1H3,(H,29,30)/t13-,18+,19+,20-,21+,23-/m1/s1/i2D,3D,4D,5D,6D
InChI Key	PMDWDAGKJPXGPP-ARBRRKMASA-N
Purity	> 98%

Apomorphine Glucuronide-[d5], a specialized derivative of Apomorphine, finds applications in diverse research and clinical settings. Delve into the following key applications with heightened perplexity and burstiness:

Pharmacokinetics Studies: Delving into pharmacokinetics, Apomorphine Glucuronide-[d5] serves as a critical tool for exploring the absorption, distribution, metabolism, and excretion dynamics of Apomorphine within the body. Its isotopic labeling facilitates precise tracing and quantification through advanced mass spectrometry techniques. This investigative approach empowers researchers to unravel the intricate interplay of Apomorphine within biological systems, guiding the optimization of dosing regimens for therapeutic utility.

Neuropharmacology Research: Within the realm of neuropharmacology, Apomorphine Glucuronide-[d5] plays a pivotal role in deciphering the drug's interactions with dopamine receptors in the brain. By scrutinizing receptor binding and activity levels, scientists glean profound insights into the mechanisms of Apomorphine and its potential side effects. This knowledge, essential for crafting treatments for neurological ailments like Parkinson's disease, sheds light on the intricate workings of the brain's biochemical pathways.

Drug Metabolism Analysis: As a cornerstone in drug metabolism analysis, Apomorphine Glucuronide-[d5] stands as a benchmark for studies unraveling the metabolic pathways of Apomorphine. Researchers can meticulously examine how the drug undergoes metabolization into glucuronide conjugates, unraveling potential metabolites along the way. This comprehensive understanding of drug metabolism is vital for discerning intricate drug-drug interactions and ensuring safety profiles in human subjects.