D-glucose-[1,5,6-13C3]

D-glucose-[1,5,6-13C3], a stable isotope-labeled glucose molecule, is widely utilized in bioscience and medical research. Here are the key applications of D-glucose-[1,5,6-13C3]:

Metabolic Flux Analysis: Leveraging D-glucose-[1,5,6-13C3] in metabolic flux analysis allows researchers to meticulously trace metabolic pathways and quantify carbon flow through diverse metabolic routes. This sophisticated method provides profound insights into cellular metabolism under fluctuating conditions, playing a pivotal role in metabolic engineering, therapeutic interventions, and gaining deep insights into disease metabolism.

NMR Spectroscopy: Applied in nuclear magnetic resonance (NMR) spectroscopy, D-glucose-[1,5,6-13C3] enables the detailed study of glucose metabolism within cells and tissues. The 13C labels yield intricate information on carbon atom transitions and the dynamic structure of glucose within biological systems, particularly crucial in cancer research, where aberrant glucose metabolism signifies a key feature of the disease.

Stable Isotope Resolved Metabolomics (SIRM): In SIRM studies, researchers harness D-glucose-[1,5,6-13C3] to unravel intricate metabolic networks by monitoring the integration of 13C into various metabolites. Through the analysis of extensive datasets, scientists uncover valuable insights into metabolic fluctuations, identifying pivotal disease biomarkers. This cutting-edge technique holds significance in both foundational research and clinical diagnostics.

Glycobiology Studies: Integral to glycobiology research, D-glucose-[1,5,6-13C3] assists in scrutinizing glycoproteins and glycolipids. By tracing the integration of labeled glucose into glycans, researchers delve into glycosylation patterns and their regulatory mechanisms. This knowledge contributes significantly to the development of therapeutic strategies for conditions linked to glycosylation irregularities.