D-galactitol-[3-13C]

D-galactitol-[3-13C], an isotopically labeled compound, holds diverse applications in scientific research, particularly in metabolic studies and diagnostics. Here are the key applications of D-galactitol-[3-13C]:

Metabolic Pathway Tracing: Utilizing D-galactitol-[3-13C] as a tracer unveils insights into carbohydrate metabolism. By tracing the labeled carbon atom along metabolic pathways, researchers delve into enzymatic activities and metabolic fluxes involving galactitol. This exploration is pivotal for deciphering metabolic shifts in conditions like galactosemia.

Magnetic Resonance Spectroscopy (MRS): In the realm of MRS, D-galactitol-[3-13C] emerges as a valuable tool for investigating metabolite concentrations and dynamics within tissues. The 13C label enables precise detection and quantification of galactitol in biological samples. This application proves especially beneficial for non-invasive in vivo studies, contributing significantly to the diagnosis and monitoring of metabolic disorders.

Enzyme Mechanism Studies: The incorporation of D-galactitol-[3-13C] in enzyme assays sheds light on the catalytic mechanisms of enzymes interacting with galactitol. By witnessing the processing of the 13C-labeled substrate, researchers deepen their comprehension of enzyme specificity and kinetics. This knowledge plays a pivotal role in designing enzyme inhibitors or engineering enzymes with tailored properties.

Biomedical Research: In the domain of biomedical research, D-galactitol-[3-13C] plays a critical role in studies related to metabolic disorders and genetic diseases. Its isotopic labeling unlocks sophisticated investigations into the biochemical effects of abnormal galactitol accumulation. This aids in the development of therapeutic strategies and enriches our understanding of disease pathology at a molecular level, paving the way for innovative interventions.