Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-013180 |
CAS: 101615-87-6 |
Molecular Formula: C4[13C]H10O5 |
Molecular Weight: 151.12 |
Chemical Structure |
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Description | Labelled D-Arabinose. D-Arabinose is an inhibitor of the enzyme glucose dehydrogenase. |
Synonyms | D-[2-13C]arabinose |
IUPAC Name | (2R,3R,4R)-2,3,4,5-tetrahydroxy(2-13C)pentanal |
Related CAS | 28697-53-2 (unlabelled) |
Canonical SMILES | C(C(C(C(C=O)O)O)O)O |
InChI | InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1/i3+1 |
InChI Key | PYMYPHUHKUWMLA-QWUQOAQISA-N |
D-Arabinose-[2-13C], a stable-isotope labeled compound, finds widespread use in diverse research applications. Here are the key applications of D-Arabinose-[2-13C]:
Metabolic Flux Analysis: The utility of D-Arabinose-[2-13C] shines in metabolic flux analysis, where it serves to illuminate the pathways and velocities of carbohydrate metabolism. Incorporating this labeled sugar into metabolic experiments enables scientists to track the flow of carbon atoms through intricate metabolic networks. This technique unveils detailed insights into cellular metabolism and fuels advancements in metabolic engineering endeavors.
NMR Spectroscopy: Delving into nuclear magnetic resonance (NMR) spectroscopy, D-Arabinose-[2-13C] emerges as a pivotal asset for probing the structural and functional facets of carbohydrates. The 13C label elevates the sensitivity and resolution of NMR signals, empowering researchers to unravel the nuances of carbohydrate interactions and dynamics. This application plays a critical role in deciphering the structure-function relationships of biomolecules, adding depth to our understanding of molecular intricacies.
Isotopic Tracing: In the realm of biochemical and physiological studies, D-Arabinose-[2-13C] takes on the role of an isotopic tracer, shedding light on the assimilation and distribution of carbon across diverse biological systems. By scrutinizing isotopic enrichment in tissues or metabolic products, researchers glean valuable insights into dietary absorption, nutrient utilization, and metabolic well-being. This approach is indispensable for investigating metabolic disorders and unraveling the intricacies of nutrient regulation, offering a window into physiological processes.
Enzyme Mechanism Studies: Enriching enzyme mechanism studies, D-Arabinose-[2-13C] presents itself as a key tool by furnishing a labeled substrate for tracing enzymatic conversions and reaction pathways. This labeling facilitates the identification of reaction intermediates and deepens our comprehension of enzyme kinetics. Such insights are instrumental in formulating enzyme inhibitors and forging ahead in the development of industrial biocatalysts, fueling progress in the realm of enzymology and biotechnology.
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