Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-013181 |
CAS: 139657-60-6 |
Molecular Formula: C4[13C]H10O5 |
Molecular Weight: 151.12 |
Chemical Structure |
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Description | Labelled D-Arabinose. D-Arabinose is an inhibitor of the enzyme glucose dehydrogenase. |
Synonyms | D-[5-13C]arabinose |
IUPAC Name | (2S,3R,4R)-2,3,4,5-tetrahydroxy(5-13C)pentanal |
Related CAS | 28697-53-2 (unlabelled) |
Canonical SMILES | C(C(C(C(C=O)O)O)O)O |
InChI | InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4-,5+/m1/s1/i2+1 |
InChI Key | PYMYPHUHKUWMLA-XGKUUUNUSA-N |
Melting Point | 152-154°C |
Solubility | Soluble in Water (Slightly) |
Appearance | White to Off-White Solid |
D-Arabinose-[5-13C], a labeled sugar molecule utilized as a tracer in diverse biochemical and metabolic investigations, has several key applications:
Metabolic Flux Analysis: Empowering researchers to track and quantitatively assess metabolic fluxes across cellular pathways, D-Arabinose-[5-13C] plays a pivotal role in deciphering the intricate dynamics of biochemical processes. By integrating this labeled sugar into metabolic assays, scientists gain precise insights into the carbon atom distribution throughout various metabolic pathways. This information is indispensable for unraveling the complexities of metabolic networks and optimizing strategies for metabolic engineering.
NMR Spectroscopy: With the distinctive [5-13C] label, D-Arabinose becomes a valuable asset for nuclear magnetic resonance (NMR) spectroscopy investigations. Researchers leverage this labeled sugar to delve into the structural and functional aspects of carbohydrates, exploring their interactions with proteins and other biomolecules. Through NMR spectroscopic analysis, detailed revelations into molecular conformation and dynamics are unveiled, enriching our understanding of molecular architectures.
Glycosylation Studies: Serving as a key component in glycosylation studies, D-Arabinose-[5-13C] sheds light on the intricate process of sugar molecule attachment to proteins or lipids. By meticulously tracing the labeled D-Arabinose along biosynthetic pathways, scientists delve into the mechanisms underlying glycoprotein or glycolipid formation. This knowledge deepens our comprehension of the roles played by glycosylation in both the realms of health and disease.
Isotope Dilution Analysis: In the realm of nutritional and biochemical research, D-Arabinose-[5-13C] finds its application in isotope dilution analysis, facilitating the precise quantification of naturally occurring D-Arabinose concentrations within complex biological samples. This technique enhances the accuracy and sensitivity of measurements, offering valuable data for the exploration of carbohydrate metabolism and its implications across various physiological conditions.
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