Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-003512 |
Molecular Formula: C26[13C]H26D3NO10 |
Molecular Weight: 531.53 |
Chemical Structure |
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Description | Daunorubicin-[13C,d3], is the labelled analogue of Daunorubicin. Daunorubicin is used for acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and Kaposi's sarcoma. |
Synonyms | Daunorubicin-13C,d3; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione-3C,d3 |
IUPAC Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-(trideuterio(1-13C)methoxy)-8,10-dihydro-7H-tetracene-5,12-dione |
Related CAS | 20830-81-3 (unlabelled) |
Canonical SMILES | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O |
InChI | InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1/i3+1D3 |
InChI Key | STQGQHZAVUOBTE-GRHMMMPSSA-N |
Purity | 85% (CP); 98% atom D; 98% atom 13C |
Appearance | Red to Very Dark Red Solid |
Storage | Store at -20°C, under inert atmosphere |
Daunorubicin-[13C,d3], a meticulously labeled compound, finds diverse applications in scientific realms for scrutinizing drug mechanisms and kinetics with utmost precision. Here are the key applications of Daunorubicin-[13C,d3]:
Pharmacokinetic Studies: Leveraging Daunorubicin-[13C,d3], researchers delve into the intricate processes of drug absorption distribution metabolism and excretion within biological systems. By employing labeled compounds, scientists can precisely quantify drug concentrations and metabolites in both plasma and tissues furnishing vital data for optimizing dosing regimens and comprehending drug behavior within the body's dynamic milieu.
Mechanistic Enzyme Studies: This variant of daunorubicin serves as a potent tool in unraveling the complexities of enzyme-drug interactions particularly with enzymes like topoisomerase II. Through the integration of stable isotopes, scientists glean detailed insights into enzyme-drug complexes reaction kinetics and the mechanisms governing drug actions. These studies play a pivotal role in the design of more potent chemotherapy agents propelling forward the frontiers of cancer treatment.
Metabolomics: Daunorubicin-[13C,d3] emerges as an indispensable asset in the realm of metabolomics facilitating the identification and quantification of daunorubicin metabolites through advanced mass spectrometry techniques. The incorporation of stable isotopic labeling enables precise discrimination between parent drugs and their metabolites within complex biological matrices shedding light on metabolic pathways and potential drug-related side effects with unparalleled clarity.
Drug Resistance Research: In the context of cancer research, Daunorubicin-[13C,d3] emerges as a powerful tool for unraveling the intricate mechanisms underlying drug resistance in malignant cells. By monitoring the trajectory of labeled daunorubicin, researchers dissect how resistant cells modulate drug metabolism or efflux mechanisms. This profound understanding is essential for devising innovative strategies to circumvent resistance and enhance the efficacy of chemotherapeutic agents championing the fight against cancer.
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