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Desloratadine-[3,3,5,5-d4]

General Information
Catalog: BLP-013910
CAS: 2713301-38-1
Molecular Formula: C19H15D4ClN2
Molecular Weight: 314.85
Chemical Structure
Desloratadine-[3,3,5,5-d4]
Description One of the isotopic labelled form of Desloratadine, which is an active metabolite of Loratadine.
Synonyms Desloratadine-d4; piperidinylidene-3,3,5,5-d4
Related CAS 100643-71-8 (unlabelled)
Purity 95% by HPLC; 98% atom D
Appearance White to off-white solid
Storage - 20 °C

Desloratadine-[3,3,5,5-d4], a deuterium-labeled iteration of the antihistamine desloratadine, plays a pivotal role in in-depth pharmacokinetic investigations and analytical research. Below are the key applications of Desloratadine-[3,3,5,5-d4]:

Pharmacokinetic Studies: Employing Desloratadine-[3,3,5,5-d4], researchers delve into the intricate realm of desloratadine’s metabolism and pharmacokinetics within the human body. The deuterium labeling facilitates precise tracking and differentiation from the non-labeled compound, enabling comprehensive analyses of absorption, distribution, metabolism, and excretion (ADME) with heightened accuracy.

Drug Interaction Studies: In the realm of clinical pharmacology, Desloratadine-[3,3,5,5-d4] is a valuable tool for exploring potential interactions with other medications. The labeled compound aids in pinpointing metabolic pathways and enzyme involvement in drug interactions, laying the foundation for a thorough comprehension of the safety and efficacy of desloratadine when administered alongside other drugs.

Analytical Method Development: Desloratadine-[3,3,5,5-d4] assumes a crucial role as an internal standard in the refinement of analytical methodologies for quantifying desloratadine levels. The stable isotope labeling serves as a benchmark for mass spectrometry and other analytical approaches, ensuring heightened reliability and precision in the determination of desloratadine concentrations across varied samples.

Biosimilar Research: Within the realm of biosimilar antihistamine development, Desloratadine-[3,3,5,5-d4] emerges as a key player in the evaluation of pharmacokinetics and bioavailability of novel formulations relative to the original drug. Its utilization facilitates the comparison to guarantee equivalent efficacy and safety profiles, a prerequisite for securing regulatory approval and market entry of biosimilar products.

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