CAS 1261393-39-8 Droxidopa-[13C7] Hydrochloride

General Information
Catalog: BLP-005257
CAS: 1261393-39-8
Molecular Formula: C2[13C]7H12ClNO5
Molecular Weight: 256.6

General Information

Catalog: BLP-005257

CAS: 1261393-39-8

Molecular Formula: C2[13C]7H12ClNO5

Molecular Weight: 256.6

Chemical Structure

Description	Droxidopa-[13C7] Hydrochloride, is the labelled analogue of Droxidopa. Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). It is capable of crossing the protective blood-brain barrier.
Synonyms	Droxidopa Hydrochloride 13C7; [13C7]-Droxidopa hydrochloride
IUPAC Name	(2S,3R)-2-amino-3-(3,4-dihydroxy(1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl)-3-hydroxy(3-13C)propanoic acid;hydrochloride
Related CAS	23651-95-8 (unlabelled free base)
Canonical SMILES	C1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O.Cl
InChI	InChI=1S/C9H11NO5.ClH/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4;/h1-3,7-8,11-13H,10H2,(H,14,15);1H/t7-,8+;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,8+1;
InChI Key	FFEWFMCABUNGJJ-BVZAOPIQSA-N
Storage	Store at -20°C

Droxidopa-[13C7] Hydrochloride, a derivative of the drug droxidopa, is commonly employed in research settings to study its pharmacokinetics and mechanism of action. Here are key applications of Droxidopa-[13C7] Hydrochloride presented with high perplexity and burstiness:

Clinical Research: In the realm of clinical investigations, Droxidopa-[13C7] Hydrochloride takes center stage, enabling researchers to meticulously track and analyze the pharmacokinetics of droxidopa within the human body. The isotopic labeling facilitates precise tracing and measurement of the drug's absorption, distribution, metabolism, and excretion processes.

Pharmacodynamics Studies: The pivotal role played by Droxidopa-[13C7] Hydrochloride extends to examining the pharmacodynamic effects of droxidopa, shedding light on its mode of action. By monitoring the drug's interaction with the body over time, researchers can draw correlations between its effects and physiological responses. This nuanced understanding aids in elucidating the therapeutic advantages and potential adverse effects of droxidopa in managing disorders associated with low blood pressure and autonomic dysfunction.

Metabolomics Research: Positioned as a cornerstone in metabolomics investigations, Droxidopa-[13C7] Hydrochloride emerges as a crucial tool for delving into metabolic pathways and drug metabolism dynamics. By introducing the labeled compound into biological systems, scientists can discern and quantify metabolic byproducts with precision. This information holds significant value in deciphering how droxidopa undergoes conversion into active forms and in exploring metabolic perturbations in pathological conditions.

Drug Development: At the frontier of preclinical and clinical drug development, Droxidopa-[13C7] Hydrochloride plays a pivotal role in evaluating the impact of structural alterations on the pharmacological profile of droxidopa. Leveraging isotopic tracing techniques, researchers can assess the stability and bioavailability of potential novel formulations. The profound insights gleaned pave the path for designing more efficacious droxidopa-based therapies, heralding a new era of therapeutic innovations.