L-Serine-[d7]

L-Serine-[d7], a deuterated variant of the amino acid L-Serine, finds extensive usage across diverse research and analytical realms. Here are the key applications of L-Serine-[d7]:

Metabolomics: Serving as an internal standard in mass spectrometry-guided metabolomics studies, L-Serine-[d7] plays a pivotal role in precisely quantifying endogenous L-serine levels within biological samples. This incorporation facilitates the monitoring of metabolic fluctuations, shedding light on disease mechanisms and cellular responses at a nuanced level.

Protein Structure Analysis: Within the domain of NMR spectroscopy, the utilization of L-Serine-[d7] is instrumental in exploring protein structural dynamics. The deuterated nature of L-serine simplifies NMR spectra, easing the task of peak assignment and enabling in-depth analysis of protein folding, interactions, and conformational transitions. This knowledge is indispensable for drug development endeavors and unraveling the intricacies of protein functionality.

Isotope Tracing Studies: Employed in metabolic flux analyses, L-Serine-[d7] aids in tracing metabolic pathways and deciphering the fate of carbon atoms during biochemical reactions. By tracking the integration of deuterium-labeled L-serine into metabolic intermediates, scientists gain valuable insights into metabolic routes and regulatory machinations. This insight fuels the refinement of metabolic engineering strategies and enriches our comprehension of cellular metabolism dynamics.

Clinical Research: In the realm of clinical investigation, L-Serine-[d7] serves as a valuable tool for probing amino acid metabolism in patient cohorts. By administering deuterated L-serine and scrutinizing its distribution and metabolic pathways, researchers glean critical understandings of conditions ranging from metabolic disorders to neurological ailments and even cancer. This knowledge serves as a cornerstone for crafting tailored therapeutic interventions and advancing our understanding of disease progression pathways.