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Floctafenine-[d5]

General Information
Catalog: BLP-005473
CAS: 1794884-17-5
Molecular Formula: C20H12D5F3N2O4
Molecular Weight: 411.39
Chemical Structure
Floctafenine-[d5]
Description Floctafenine-[d5] is the labelled analogue of Floctafenine. Floctafenine is a nonsteroidal anti-inflammatory drug.
Synonyms Floctafenine D5
IUPAC Name (1,1,2,3,3-pentadeuterio-2,3-dihydroxypropyl) 2-[[8-(trifluoromethyl)quinolin-4-yl]amino]benzoate
Related CAS 23779-99-9 (unlabelled)
Canonical SMILES C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F
InChI InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)/i10D2,11D2,12D
InChI Key APQPGQGAWABJLN-XPZONWKMSA-N
Boiling Point 592.1±50.0°C at 760 mmHg
Density 1.4±0.1 g/cm3
Storage Store at 2-8°C

Floctafenine-[d5], a deuterated variant of the non-steroidal anti-inflammatory drug floctafenine, serves primarily for analytical and research purposes. Here are key applications of Floctafenine-[d5] presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: In the realm of pharmacokinetics, Floctafenine-[d5] is a valuable asset for monitoring the absorption, distribution, metabolism, and excretion of floctafenine within the body. Acting as an isotopic label, the deuterated form enables precise quantification through mass spectrometry, shedding light on the drug's behavior and aiding in the optimization of dosing regimens.

Metabolism Research: Within the realm of drug metabolism exploration, Floctafenine-[d5] plays a pivotal role in uncovering metabolic pathways and potential metabolites of floctafenine. Through an in-depth analysis of the deuterium-labeled compound, researchers can pinpoint sites of metabolic transformation, offering critical insights for predicting drug interactions and enhancing drug safety profiles.

Analytical Chemistry: Delving into the domain of analytical chemistry, Floctafenine-[d5] functions as an internal standard for quantifying floctafenine within biological samples. Its stable isotopic composition facilitates accurate and reproducible measurements, thereby bolstering the reliability of analytical methodologies. This application proves particularly beneficial in clinical and forensic toxicology settings, enabling the precise monitoring of drug levels.

Drug Development: When it comes to drug development endeavors, Floctafenine-[d5] emerges as a valuable tool for investigating the effects of deuteration on the pharmacological attributes of floctafenine. Researchers delve into how the substitution of hydrogen atoms with deuterium influences potency, duration of action, and side effect profiles, paving the way for the formulation of more efficient and safer drug formulations.

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