Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-005473 |
CAS: 1794884-17-5 |
Molecular Formula: C20H12D5F3N2O4 |
Molecular Weight: 411.39 |
Chemical Structure |
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Description | Floctafenine-[d5] is the labelled analogue of Floctafenine. Floctafenine is a nonsteroidal anti-inflammatory drug. |
Synonyms | Floctafenine D5 |
IUPAC Name | (1,1,2,3,3-pentadeuterio-2,3-dihydroxypropyl) 2-[[8-(trifluoromethyl)quinolin-4-yl]amino]benzoate |
Related CAS | 23779-99-9 (unlabelled) |
Canonical SMILES | C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F |
InChI | InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)/i10D2,11D2,12D |
InChI Key | APQPGQGAWABJLN-XPZONWKMSA-N |
Boiling Point | 592.1±50.0°C at 760 mmHg |
Density | 1.4±0.1 g/cm3 |
Storage | Store at 2-8°C |
Floctafenine-[d5], a deuterated variant of the non-steroidal anti-inflammatory drug floctafenine, serves primarily for analytical and research purposes. Here are key applications of Floctafenine-[d5] presented with a high degree of perplexity and burstiness:
Pharmacokinetic Studies: In the realm of pharmacokinetics, Floctafenine-[d5] is a valuable asset for monitoring the absorption, distribution, metabolism, and excretion of floctafenine within the body. Acting as an isotopic label, the deuterated form enables precise quantification through mass spectrometry, shedding light on the drug's behavior and aiding in the optimization of dosing regimens.
Metabolism Research: Within the realm of drug metabolism exploration, Floctafenine-[d5] plays a pivotal role in uncovering metabolic pathways and potential metabolites of floctafenine. Through an in-depth analysis of the deuterium-labeled compound, researchers can pinpoint sites of metabolic transformation, offering critical insights for predicting drug interactions and enhancing drug safety profiles.
Analytical Chemistry: Delving into the domain of analytical chemistry, Floctafenine-[d5] functions as an internal standard for quantifying floctafenine within biological samples. Its stable isotopic composition facilitates accurate and reproducible measurements, thereby bolstering the reliability of analytical methodologies. This application proves particularly beneficial in clinical and forensic toxicology settings, enabling the precise monitoring of drug levels.
Drug Development: When it comes to drug development endeavors, Floctafenine-[d5] emerges as a valuable tool for investigating the effects of deuteration on the pharmacological attributes of floctafenine. Researchers delve into how the substitution of hydrogen atoms with deuterium influences potency, duration of action, and side effect profiles, paving the way for the formulation of more efficient and safer drug formulations.
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