Name: Olmesartan Acid-[d6]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-012495

CAS: 1185144-74-4

Molecular Formula: C24H20D6N6O3

Molecular Weight: 452.54

Chemical Structure

Description	Olmesartan Acid-[d6] is the labelled analogue of Olmesartan Acid. Olmesartan Acid is an angiotensin II receptor antagonist and can be used as an anti-hypertensive.
Synonyms	Olmesartan D6 Acid; 4-(1-Hydroxy-1-methylethyl-d6)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
IUPAC Name	5-(1,1,1,3,3,3-hexadeuterio-2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
Related CAS	144689-24-7 (unlabelled)
Canonical SMILES	CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)O
InChI	InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)/i2D3,3D3
InChI Key	VTRAEEWXHOVJFV-XERRXZQWSA-N
Melting Point	>174°C (dec.)
Purity	98% by HPLC; 98% atom D
Solubility	Soluble in DMSO, Methanol
Appearance	White to Off-white Solid
Storage	Store at -20°C

Olmesartan Acid-[d6], a deuterium-labeled analog of Olmesartan, finds widespread use in diverse research contexts. Here are the key applications of Olmesartan Acid-[d6]:

Pharmacokinetic Studies: Olmesartan Acid-[d6] plays a pivotal role in pharmacokinetic investigations, facilitating the meticulous tracking of Olmesartan’s absorption, distribution, metabolism, and excretion within the body. The incorporation of a deuterium label enables precise measurements via mass spectrometry, offering deep insights into the drug's behavior across various tissues. This data is paramount for optimizing dosing strategies and enhancing therapeutic outcomes.

Metabolic Pathway Elucidation: By integrating Olmesartan Acid-[d6] into metabolic research, scientists can delve into the intricate metabolic pathways and biotransformation products of Olmesartan. The utilization of a deuterium label provides a unique tracer, simplifying the identification and characterization of metabolites. Such revelations contribute significantly to understanding the drug's metabolic processes and its potential interactions with other substances.

Drug Interaction Studies: Olmesartan Acid-[d6] serves as a valuable tool for exploring drug-drug interactions, acting as a stable isotopic reference standard. Researchers can accurately quantify Olmesartan levels in conjunction with other medications, assessing how various therapeutic agents impact its pharmacokinetics. This analysis is crucial for evaluating potential adverse effects and ensuring the safe co-administration of different drugs.

Analytical Method Development: The application of Olmesartan Acid-[d6] is instrumental in the development and validation of analytical methods for the detection and quantification of Olmesartan in biological samples. Its stable isotopic nature acts as an internal standard, enhancing the accuracy and reproducibility of assays. This utilization is foundational for drug analysis and quality assurance in pharmaceutical research, underpinning the reliability of analytical procedures.