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Ondansetron-[d3]

General Information
Catalog: BLP-003666
CAS: 1132757-82-4
Molecular Formula: C18H16D3N3O
Molecular Weight: 296.4
Chemical Structure
Ondansetron-[d3]
Description Ondansetron-[d3], is the labelled analogue of Ondansetron, which is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
Synonyms Ondansetron D3
IUPAC Name 3-[(2-methylimidazol-1-yl)methyl]-9-(trideuteriomethyl)-2,3-dihydro-1H-carbazol-4-one
Related CAS 99614-02-5 (unlabelled)
Canonical SMILES CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3/i2D3
InChI Key FELGMEQIXOGIFQ-BMSJAHLVSA-N
Boiling Point 546.0±30.0°C at 760 mmHg
Melting Point 231-232°C
Purity 98% by CP; 98% atom D
Density 1.3±0.1 g/cm3
Solubility Soluble in DMSO, Methanol
Appearance White to Off-white Solid
Storage Store at-20°C, Under inert atmosphere

Ondansetron-[d3], a labeled compound utilized primarily in research settings, plays a pivotal role in studying the pharmacokinetics and metabolism of ondansetron, an antiemetic medication. Here are key applications of Ondansetron-[d3] presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: Applying Ondansetron-[d3] in pharmacokinetic investigations allows researchers to delve into the intricate dynamics of ondansetron's absorption, distribution, metabolism, and excretion within the body. By harnessing this deuterium-labeled compound, scientists can meticulously trace the drug's journey through the biological terrain with unparalleled precision. This data serves as a cornerstone for refining dosing protocols and unraveling the complexities of drug interactions.

Drug Metabolism Research: The labeled compound Ondansetron-[d3] acts as a linchpin in unraveling the metabolic pathways of ondansetron. Researchers leverage this tool to pinpoint metabolites and unravel the intricate dance of enzymes in the drug's biotransformation.

Bioequivalence Studies: In the realm of bioequivalence scrutiny, Ondansetron-[d3] empowers researchers to juxtapose generic iterations of ondansetron against the original branded variant. By scrutinizing the pharmacokinetic profiles of both, scientists can ascertain the therapeutic equivalence of the generic formulation. This meticulous comparison underpins regulatory green lights and safeguards the efficacy and safety of generic pharmaceuticals.

Analytical Method Development: Ondansetron-[d3] serves as a cornerstone in crafting and validating analytical methodologies for quantifying ondansetron levels in biological fluids. The stable isotope tag offers a reliable internal benchmark for sophisticated techniques such as mass spectrometry. Precise quantification underpins a myriad of research and clinical endeavors revolving around ondansetron, facilitating impactful advancements in the field.

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