Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-003666 |
CAS: 1132757-82-4 |
Molecular Formula: C18H16D3N3O |
Molecular Weight: 296.4 |
Chemical Structure |
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Description | Ondansetron-[d3], is the labelled analogue of Ondansetron, which is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
Synonyms | Ondansetron D3 |
IUPAC Name | 3-[(2-methylimidazol-1-yl)methyl]-9-(trideuteriomethyl)-2,3-dihydro-1H-carbazol-4-one |
Related CAS | 99614-02-5 (unlabelled) |
Canonical SMILES | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C |
InChI | InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3/i2D3 |
InChI Key | FELGMEQIXOGIFQ-BMSJAHLVSA-N |
Boiling Point | 546.0±30.0°C at 760 mmHg |
Melting Point | 231-232°C |
Purity | 98% by CP; 98% atom D |
Density | 1.3±0.1 g/cm3 |
Solubility | Soluble in DMSO, Methanol |
Appearance | White to Off-white Solid |
Storage | Store at-20°C, Under inert atmosphere |
Ondansetron-[d3], a labeled compound utilized primarily in research settings, plays a pivotal role in studying the pharmacokinetics and metabolism of ondansetron, an antiemetic medication. Here are key applications of Ondansetron-[d3] presented with a high degree of perplexity and burstiness:
Pharmacokinetic Studies: Applying Ondansetron-[d3] in pharmacokinetic investigations allows researchers to delve into the intricate dynamics of ondansetron's absorption, distribution, metabolism, and excretion within the body. By harnessing this deuterium-labeled compound, scientists can meticulously trace the drug's journey through the biological terrain with unparalleled precision. This data serves as a cornerstone for refining dosing protocols and unraveling the complexities of drug interactions.
Drug Metabolism Research: The labeled compound Ondansetron-[d3] acts as a linchpin in unraveling the metabolic pathways of ondansetron. Researchers leverage this tool to pinpoint metabolites and unravel the intricate dance of enzymes in the drug's biotransformation.
Bioequivalence Studies: In the realm of bioequivalence scrutiny, Ondansetron-[d3] empowers researchers to juxtapose generic iterations of ondansetron against the original branded variant. By scrutinizing the pharmacokinetic profiles of both, scientists can ascertain the therapeutic equivalence of the generic formulation. This meticulous comparison underpins regulatory green lights and safeguards the efficacy and safety of generic pharmaceuticals.
Analytical Method Development: Ondansetron-[d3] serves as a cornerstone in crafting and validating analytical methodologies for quantifying ondansetron levels in biological fluids. The stable isotope tag offers a reliable internal benchmark for sophisticated techniques such as mass spectrometry. Precise quantification underpins a myriad of research and clinical endeavors revolving around ondansetron, facilitating impactful advancements in the field.
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