Name: Osilodrostat-[13C,d4,15N]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003689

Molecular Formula: C12[13C]H6D4FN2[15N]

Molecular Weight: 233.25

Chemical Structure

Description	Osilodrostat-[13C,d4,15N], is an isotope labelled derivative of Osilodrostat. Osilodrostat, also called as LCI699, is a modulator of 11-β-hydroxylase (IC50= 2.5 nM), useful for treating a disorder ameliorated 11-β-hydroxylase inhibition, and a potent inhibitor of aldosterone synthase (IC50= 0.7 nM).
Synonyms	Osilodrostat-13C-D4-15N
IUPAC Name	3-fluoro-4-[(5R)-6,6,7,7-tetradeuterio-5H-pyrrolo[1,2-c]imidazol-5-yl](15N)benzonitrile
Related CAS	928134-65-0 (unlabelled)
Canonical SMILES	C1CC2=CN=CN2C1C3=C(C=C(C=C3)C#N)F
InChI	InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1/i2D2,4D2,6+1,15+1
InChI Key	USUZGMWDZDXMDG-RVQPWHPNSA-N
Solubility	Soluble in DMSO

Osilodrostat-[13C,d4,15N], a stable isotope-labeled compound used extensively in pharmacological research, serves various critical functions. Here are key applications of Osilodrostat-[13C,d4,15N], presented with a high degree of perplexity and burstiness:

Pharmacokinetics Studies: Delving into the intricate world of pharmacokinetics, Osilodrostat-[13C,d4,15N] plays a pivotal role in unraveling the behavior of the drug osilodrostat, a treatment for Cushing's disease. By meticulously tracking the labeled isotopes in biological samples, researchers gain precise insights into the absorption, distribution, metabolism, and excretion profiles of the drug. This detailed data not only informs optimal drug dosing regimens but also elevates the comprehension of the drug's dynamics within the body.

Metabolite Identification: In the realm of drug metabolism studies, Osilodrostat-[13C,d4,15N] emerges as a key player in identifying and characterizing osilodrostat metabolites. Leveraging stable isotopes, researchers can clearly differentiate between parent compounds and metabolites in mass spectrometry analysis. This approach empowers researchers to intricately map out metabolic pathways and comprehensively evaluate the safety and efficacy of the drug, fostering a deeper understanding of its pharmacological behavior.

Drug Interaction Analysis: Aiding in the exploration of potential drug-drug interactions, Osilodrostat-[13C,d4,15N] offers invaluable insights. Researchers utilize the labeled compound to observe how co-administered drugs impact osilodrostat's metabolism.

Biosynthetic Pathway Tracing: Foraying into the realm of biochemical research, the isotopic labeling of Osilodrostat-[13C,d4,15N] serves as a guiding light in tracing biosynthetic pathways within organisms. Researchers can meticulously track the incorporation of labeled atoms into metabolic intermediates and end products, unraveling the intricacies of complex biochemical networks. This insight is vital for deciphering the intricate dance of biological processes and holds immense promise for applications in systems biology and metabolic engineering, unlocking new horizons in scientific exploration.