Name: Pirenzepine-[d8]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003834

CAS: 1189944-02-2

Molecular Formula: C19H13D8N5O2

Molecular Weight: 359.45

Chemical Structure

Description	Pirenzepine-[d8], is the labelled analogue of Pirenzepine. Pirenzepine, an M1 selective antagonist, is used in the treatment of peptic ulcers.
Synonyms	Pirenzepine D8; 11-{[4-Methyl(2H8)piperazin-1-yl]acetyl}-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
IUPAC Name	11-[2-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Related CAS	28797-61-7 (unlabelled)
Isomeric SMILES	[2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)([2H])[2H])[2H]
Canonical SMILES	CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
InChI	InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/i9D2,10D2,11D2,12D2
InChI Key	RMHMFHUVIITRHF-PMCMNDOISA-N
Purity	>98%
Storage	Store at-20°C

Pirenzepine-[d8] is a deuterium-labeled form of pirenzepine, primarily used as a research tool in pharmacology and medicinal chemistry. Here are some key applications of Pirenzepine-[d8]:

Pharmacokinetic Studies: Pirenzepine-[d8] is employed as an internal standard in pharmacokinetic studies to accurately measure the concentration of pirenzepine in biological samples. Its isotopic label allows for precise quantification using techniques such as mass spectrometry. This facilitates the assessment of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.

Receptor Binding Studies: In receptor binding assays, Pirenzepine-[d8] is used to investigate the binding affinity and specificity of pirenzepine for muscarinic receptors. By incorporating the deuterium-labeled compound, researchers can differentiate between endogenous and exogenous sources of the ligand. This helps in understanding receptor-ligand interactions and the pharmacological profile of muscarinic antagonists.

Chemical Synthesis Research: Pirenzepine-[d8] serves as a valuable tool in the synthesis and development of new muscarinic receptor antagonists. Researchers use it to explore the structural activity relationship and to design ligands with enhanced binding properties or therapeutic profiles. The presence of the deuterium label aids in tracking metabolic pathways and improving drug stability studies.

Drug Metabolism Studies: In drug metabolism research, Pirenzepine-[d8] is used to study the metabolic pathways and rates of pirenzepine in various biological systems. By labeling the compound with deuterium, scientists can distinguish between metabolic products and gain insights into the mechanisms of drug metabolism. This information is essential for optimizing drug formulations and predicting potential drug-drug interactions.