Propiverine-[d5] - Isotope / BOC Sciences

General Information
Catalog: BLP-003911
Molecular Formula: C23H24D5NO3
Molecular Weight: 372.51

General Information

Catalog: BLP-003911

Molecular Formula: C23H24D5NO3

Molecular Weight: 372.51

Chemical Structure

Description	Propiverine-[d5], is the labelled analogue of Propiverine. Propiverine is a muscarinic antagonist. It is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence.
Synonyms	Propiverine D5
IUPAC Name	(3,3,4,5,5-pentadeuterio-1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate
Related CAS	60569-19-9 (unlabelled)
Canonical SMILES	CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C
InChI	InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3/i14D2,15D2,21D
InChI Key	QPCVHQBVMYCJOM-PXQVSKJUSA-N
Purity	>98%
Storage	Store at-20°C

Propiverine-[d5] is an isotopically labeled compound commonly used in scientific research and pharmaceutical studies. Here are some key applications of Propiverine-[d5]:

Pharmacokinetics Studies: Propiverine-[d5] is utilized as a tracer in pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion (ADME) of propiverine in the body. By using the deuterium-labeled compound, researchers can accurately track the drug's behavior without interference from endogenous substances. This helps in determining dosage regimens and optimizing therapeutic efficacy.

Metabolite Identification: In metabolic research, Propiverine-[d5] plays a crucial role in identifying and quantifying metabolites of propiverine. Mass spectrometry techniques can differentiate between the labeled drug and its metabolites, providing insights into metabolic pathways and transformation processes. This information is essential for assessing drug safety and potential interactions.

Bioanalytical Method Development: Propiverine-[d5] is used in the development and validation of bioanalytical methods such as liquid chromatography-mass spectrometry (LC-MS). The labeled compound serves as an internal standard, ensuring accurate measurement of propiverine concentrations in biological samples. This is critical for regulatory approval and quality control in drug manufacturing.

Drug Interaction Studies: Researchers employ Propiverine-[d5] in studies to investigate potential drug-drug interactions involving propiverine. By observing how the presence of other drugs affects the pharmacokinetics of Propiverine-[d5], scientists can predict possible adverse effects or modified efficacy when administered with other medications.