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(R)-Crizotinib-[d5] (piperidine-[3,3,4,5,5-d5])

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General Information
Catalog: BLP-013941
CAS: 1395950-84-1
Molecular Formula: C21H17D5Cl2FN5O
Molecular Weight: 455.37

Chemical Structure

Description	One of the isotopic labelled form of (R)-Crizotinib, which is probably be a potent ALK inhibitor as well as c-MET inhibitor.
Synonyms	(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine
IUPAC Name	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(3,3,4,5,5-pentadeuteriopiperidin-4-yl)pyrazol-4-yl]pyridin-2-amine
Related CAS	877399-52-5 (unlabelled)
Canonical SMILES	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChI	InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1/i4D2,5D2,15D
InChI Key	KTEIFNKAUNYNJU-LJIFSARKSA-N
Melting Point	197-199°C
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance	Brown to Very Dark Brown Solid