Name: rac Phenylephrine-[d3] Hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004036

Molecular Formula: C9H11D3ClNO2

Molecular Weight: 206.68

Chemical Structure

Description	Rac Phenylephrine-[d3] Hydrochloride is an isotope labelled form of Phenylephrine which is a selective α1-adrenergic receptor agonist used as a decongestant. Phenylephrine is used as an agent to dilate the pupil because it can lower intraocular pressure.
Synonyms	(±)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol-d3 Hydrochloride; (±)-m-Hydroxy-α-[(methylamino)methyl]benzyl Alcohol-d3 Hydrochloride; (±)-Phenylephrine Hydrochloride-d3; 1-(3-Hydroxyphenyl)-2-methylaminoethanol-d3 Hydrochloride; DL-Phenylephrine-d3 Hydrochloride; NSC 14029-d3
IUPAC Name	3-[1-hydroxy-2-(trideuteriomethylamino)ethyl]phenol;hydrochloride
Related CAS	154-86-9 (unlabelled) 88694-06-8 (free base)
Canonical SMILES	CNCC(C1=CC(=CC=C1)O)O.Cl
InChI	InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/i1D3;
InChI Key	OCYSGIYOVXAGKQ-NIIDSAIPSA-N
Purity	>98%

rac Phenylephrine-[d3] Hydrochloride, a deuterated variant of the well-known sympathomimetic agent phenylephrine, finds diverse applications in research and clinical domains. Here are crucial applications presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: Employing rac Phenylephrine-[d3] Hydrochloride in pharmacokinetic investigations enhances insights into the absorption, distribution, metabolism, and excretion pathways of phenylephrine. The deuterated formulation facilitates precise tracking via mass spectrometry, enabling nuanced understanding for optimizing dosage regimens and ensuring the safety and efficacy of the drug in clinical scenarios.

Receptor Binding Research: In scientific inquiries, rac Phenylephrine-[d3] Hydrochloride plays a pivotal role in probing adrenergic receptor interactions owing to its agonistic properties. By leveraging the deuterated version, researchers can differentiate between sources of endogenous and exogenous compounds in receptor binding assays, shedding light on receptor dynamics and fostering the development of targeted adrenergic therapies.

Isotope Dilution Methods: Acting as an internal standard in isotope dilution mass spectrometry, rac Phenylephrine-[d3] Hydrochloride enables accurate quantification of phenylephrine in biological samples. Its inclusion as a standard ensures precise measurements in bioanalytical methodologies, crucial for drug development and therapeutic monitoring processes.

Clinical Pharmacology: In the realm of clinical pharmacology, rac Phenylephrine-[d3] Hydrochloride emerges as a valuable tool for investigating the effects of phenylephrine across various physiological contexts. Its utilization aids in assessing the drug's influence on parameters such as blood pressure and vascular resistance.