Name: Rebamipide-[d4]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004108

CAS: 1219409-06-9

Molecular Formula: C19H11D4ClN2O4

Molecular Weight: 374.81

Chemical Structure

Description	Labelled Rebamipide. Rebamipide has been shown to enhance mucosal defense by scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.
Synonyms	α-[(4-Chlorobenzoyl-d4)-amino]-1;2-dihydro-2-oxo-4-quinolinepropanoic Acid; OPC-12759-d4; Mucosta-d4; Proamipide-d4
IUPAC Name	2-[(4-chloro-2,3,5,6-tetradeuteriobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
Related CAS	90098-04-7 (unlabelled)
Canonical SMILES	C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
InChI	InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)/i5D,6D,7D,8D
InChI Key	ALLWOAVDORUJLA-KDWZCNHSSA-N
Melting Point	290-294°C(dec.)
Purity	≥90%
Solubility	Soluble in DMSO
Appearance	Off-white to White Solid
Storage	Store at-20°C

Rebamipide-[d4], an isotopically labeled derivative of Rebamipide, finds widespread application in research environments for investigating its pharmacokinetics and biological impacts. Here are key applications of Rebamipide-[d4], presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: In the realm of pharmacokinetic inquiries, Rebamipide-[d4] plays a crucial role as a tool for monitoring the absorption, distribution, metabolism, and excretion of Rebamipide within the body. Through the utilization of this deuterium-labeled variant, researchers can achieve precise quantification, gaining profound insights into the compound's half-life and bioavailability. This meticulous analysis is paramount for fine-tuning dosing schedules and optimizing drug effectiveness.

Metabolism Research: Within the scope of metabolism exploration, Rebamipide-[d4] acts as a tracer, facilitating investigations into the metabolic pathways and transformations occurring within the body. The employment of isotopic labeling aids in distinguishing the parent compound from its metabolites, a critical step in understanding metabolic stability and identifying potential biotransformation products. Such knowledge holds immense importance in drug development and safety evaluation.

Drug Interaction Studies: Rebamipide-[d4] is a valuable asset in scrutinizing potential drug-drug interactions involving Rebamipide. By observing alterations in pharmacokinetic profiles when Rebamipide is co-administered with other compounds, researchers can anticipate interactions that may impact therapeutic outcomes significantly.

Mucosal Protective Mechanisms: Delving into the mechanisms underlying mucosal protection, Rebamipide-[d4] offers insight into how Rebamipide bolsters mucosal safeguarding in conditions like gastric ulcers. By tracing the labeled compound in cellular and tissue models, scientists can delve into the drug's impact on mucosal mending processes and inflammatory responses. This application fosters the development of more potent strategies for gastrointestinal safeguarding and therapy.