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Application Area
Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic
Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry
Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Tenofovir Alafenamide-[d5] Fumarate (diastereomers)

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General Information
Catalog: BLP-004580
Molecular Formula: C25H28D5N6O9P
Molecular Weight: 481.50
Chemical Structure
Tenofovir Alafenamide-[d5] Fumarate (diastereomers)
Description A labelled form of Tenofovir alafenamide fumarate. Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate. TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir.
Synonyms GS 7171-d5 Fumarate; 1-Methylethyl Ester N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine-d5 Fumarate
Related CAS 379270-38-9 (unlabelled)
Melting Point 104-107°C (dec.)
Purity ≥90%
Solubility Soluble in DMSO, Methanol
Appearance White to Off-white Solid
Storage Hygroscopic, Store at -20°C, Under inert atmosphere
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