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2-Amino-2-deoxy-D-galactose-[1-13C,15N] hydrochloride

General Information
Catalog: BLP-012724
Molecular Formula: C5[13C]H13[15N]O5.HCl
Molecular Weight: 217.63
Chemical Structure
2-Amino-2-deoxy-D-galactose-[1-13C,15N] hydrochloride
Synonyms 2-[15N]amino-2-deoxy-D-[1-13C]galactose hydrochloride; D-[1-13C,15N]galactosamine hydrochloride; D-galactosamine-1-13C,15N hydrochloride; Chondrosamine-1-13C,15N Hydrochloride
IUPAC Name (3R,4R,5R,6R)-3-(15N)azanyl-6-(hydroxymethyl)(2-13C)oxane-2,4,5-triol;hydrochloride
Related CAS 1772-03-8 (unlabelled) 7535-00-4 (unlabelled free base)
Canonical SMILES C(C1C(C(C(C(O1)O)N)O)O)O.Cl
InChI InChI=1S/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4+,5-,6?;/m1./s1/i6+1,7+1;
InChI Key QKPLRMLTKYXDST-FJINOEKTSA-N
Solubility Soluble in Acetone (Slightly), Methanol (Very Slightly, Heated), Water (Sparingly)
Appearance Off-white Solid
Storage Store at -20°C

2-Amino-2-deoxy-D-galactose-[1-13C,15N] hydrochloride, a labeled monosaccharide of utmost significance in diverse research applications involving the monitoring and analysis of biochemical processes, offers several key applications. Here are the key applications of this compound:

Glycoprotein Research: Embarking on the intricate realm of glycoprotein studies, researchers utilize this isotopically labeled compound to unravel the complexities of glycoprotein biosynthesis and metabolism. By integrating 2-Amino-2-deoxy-D-galactose-[1-13C,15N] into glycoproteins, scientists employ mass spectrometry to decipher protein glycosylation patterns. This analytical approach sheds light on the intricate interplay between the structure and function of glycoproteins, offering insights into their pivotal roles in cellular processes.

Metabolic Flux Analysis: Within the realm of metabolic investigations, 2-Amino-2-deoxy-D-galactose-[1-13C,15N] hydrochloride emerges as a crucial tool for tracing amino sugar-related metabolic pathways. Through the utilization of nuclear magnetic resonance (NMR) spectroscopy and cutting-edge analytical methods, researchers meticulously monitor the flow of carbon and nitrogen atoms within cellular metabolites. This in-depth analysis aids in unraveling metabolic pathways and elucidating the regulatory mechanisms that govern cellular metabolism.

Cellular Labeling: Scientists leverage the dynamic capabilities of 2-Amino-2-deoxy-D-galactose-[1-13C,15N] to intricately label specific cellular components, enabling precise tracking and visualization. Particularly valuable in live cell imaging and investigations exploring cell growth, division, and differentiation, these isotopic labels act as dynamic markers for real-time monitoring of cellular dynamics. This methodology provides crucial insights into cellular processes, fostering a comprehensive understanding of cellular behavior.

Drug Development: At the forefront of pharmaceutical research, this labeled compound plays a pivotal role in examining the pharmacokinetics and mechanisms of drugs targeting glycan pathways. By monitoring the incorporation and turnover of the labeled sugar in drug compounds, researchers assess drug efficacy and metabolic stability. This essential data drives the optimization of drug designs and informs strategic therapeutic interventions, fueling advancements in the field of drug development.

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