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DL-Leucine-[2,3,3-d3]

General Information
Catalog: BLP-009771
Molecular Formula: C6H10D3NO2
Molecular Weight: 134.19
Chemical Structure
DL-Leucine-[2,3,3-d3]
Description DL-Leucine-[2,3,3-d3] is a labelled DL-Leucine. Leucine is an α-amino acid essential for humans.
IUPAC Name 2-amino-2,3,3-trideuterio-4-methylpentanoic acid
Related CAS 328-39-2 (unlabelled)
Canonical SMILES CC(C)CC(C(=O)O)N
InChI InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/i3D2,5D
InChI Key ROHFNLRQFUQHCH-MSYDVTBWSA-N
Melting Point 293-296°C (subl.)(lit.)
Purity 95% by HPLC; 98% atom D

DL-Leucine-[2,3,3-d3], an isotopically labeled derivative of the amino acid leucine, stands as a cornerstone of scientific exploration. Discover key applications of DL-Leucine-[2,3,3-d3] presented with heightened perplexity and burstiness:

Metabolic Flux Analysis: Embark on an intricate journey into metabolic studies where DL-Leucine-[2,3,3-d3] shines as a guiding beacon in unraveling the complexities of protein metabolism and turnover dynamics. This stable isotope-labeled compound acts as a navigator, leading researchers through the labyrinthine pathways of leucine within diverse metabolic networks in vivo. By shedding light on amino acid utilization dynamics and protein synthesis kinetics, this application unveils the enigmatic choreography of molecules in varied physiological and pathological settings.

Proteomics Research: Dive deep into the captivating landscape of proteomics, where DL-Leucine-[2,3,3-d3] emerges as a pivotal tool for quantitative mass spectrometry investigations. Nestled within proteins, this labeled leucine enables precise quantification of protein expression levels and post-translational modifications, illuminating the intricate interplay of proteins. In the realm of disease research, this tool becomes indispensable for unearthing cryptic biomarkers and unraveling the enigmas of protein function.

Nutritional Science: Plunge into the depths of nutritional studies, where DL-Leucine-[2,3,3-d3] acts as a guiding beacon for exploring amino acid requirements and digestion efficiencies. By integrating this labeled leucine into dietary explorations, scientists embark on a quest to decipher its absorption kinetics, bioavailability patterns, and utilization dynamics across diverse populations. This research journey informs the formulation of dietary recommendations and empowers the development of targeted nutritional interventions for enhancing well-being and combating diseases.

Biochemical Pathway Elucidation: Venture into the intricate web of biochemical pathways interwoven with branched-chain amino acids, illuminated by the beacon of DL-Leucine-[2,3,3-d3]. This labeled compound serves as a torchbearer, shedding light on the regulatory mechanisms governing leucine metabolism and its impact on complex cellular signaling cascades. The insights gleaned from this exploration deepen our understanding of intricate metabolic conditions like maple syrup urine disease, unveiling the underlying biochemical disruptions and paving the path for innovative therapeutic strategies.

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