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N-Isobutyrylglycine-[d7]

General Information
Catalog: BLP-009959
CAS: 1330037-23-4
Molecular Formula: C6H4D7NO3
Molecular Weight: 152.2
Chemical Structure
N-Isobutyrylglycine-[d7]
Description N-Isobutyrylglycine-[d7] is a labelled isobutyrylglycine. Isobutyrylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. Increased level of isobutyrylglycine in urine is associated with isobutyryl-CoA dehydrogenase deficiency.
Synonyms Isobutyrylaminoacetic Acid-d7; N-Isobutyryl-d7-glycine; N-2-Methylpropionyl-d7-glycine
IUPAC Name 2-[[2,3,3,3-tetradeuterio-2-(trideuteriomethyl)propanoyl]amino]acetic acid
Related CAS 15926-18-8 (unlabelled)
Canonical SMILES CC(C)C(=O)NCC(=O)O
InChI InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)/i1D3,2D3,4D
InChI Key DCICDMMXFIELDF-UAVYNJCWSA-N
Purity 95% by HPLC; 98% atom D

N-Isobutyrylglycine-[d7], a deuterated metabolite utilized in various biochemical and preclinical research applications, plays a pivotal role in advancing scientific knowledge. Here are the key applications of N-Isobutyrylglycine-[d7]:

Metabolomics: Acting as an internal standard in mass spectrometry-based metabolomics investigations, N-Isobutyrylglycine-[d7] facilitates the precise quantification of endogenous N-isobutyrylglycine levels in biological specimens. This accuracy is paramount in deciphering metabolic alterations linked to diseases or treatments, ensuring the generation of dependable and replicable outcomes.

Biomarker Discovery: Within the realm of clinical research, N-Isobutyrylglycine-[d7] aids in unearthing novel biomarkers for metabolic disorders. By contrasting the levels of deuterated and non-deuterated metabolites, researchers can unveil subtle shifts in metabolic pathways. This process catalyzes the identification of potential diagnostic indicators and therapeutic targets for a diverse array of conditions.

Pharmacokinetics: Harnessing the power of N-Isobutyrylglycine-[d7], scientists delve into the pharmacokinetics of drugs that impact or are impacted by N-isobutyrylglycine metabolism. Through tracking the deuterated compound, researchers scrutinize the absorption, distribution, metabolism, and excretion (ADME) patterns of substances intertwined in related pathways. This data proves indispensable in fine-tuning drug dosages and enhancing efficacy.

Toxicology: Serving as a tracer in toxicological explorations, N-Isobutyrylglycine-[d7] enables the monitoring of metabolic repercussions following exposure to toxic agents. By monitoring shifts in N-isobutyrylglycine metabolism, scientists evaluate the toxic effects and potential mechanisms of toxicity. This knowledge aids in the development of safer chemicals and the mitigation of risks associated with harmful exposures.

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