D-glucose-[1,2,4-13C3]

D-glucose-[1,2,4-13C3], an isotopically labeled glucose molecule, features three carbon atoms (C1, C2, and C4) enriched with stable carbon-13 isotopes. This unique composition makes it a versatile tool for diverse scientific pursuits. Here are the key applications of D-glucose-[1,2,4-13C3]:

Metabolic Flux Analysis: Employed extensively in metabolic flux analysis, D-glucose-[1,2,4-13C3] is pivotal for mapping the intricate pathways of glucose metabolism within cellular systems. By monitoring the carbon-13 label's distribution, researchers can quantitatively assess carbon flow across different metabolic routes. This data is paramount for comprehending the dynamic interplay of metabolic networks and pinpointing critical bottlenecks within metabolic pathways.

Magnetic Resonance Imaging (MRI): Within the realm of medical imaging, D-glucose-[1,2,4-13C3] assumes a crucial role as a contrast agent in hyperpolarized MRI investigations. The presence of 13C-labeled glucose amplifies MRI signals, enabling real-time visualization of glucose uptake and metabolism in tissues. This application proves particularly valuable in cancer diagnostics and monitoring tumor metabolism, providing invaluable insights into disease progression.

Stable Isotope Labeling in Biochemistry: Researchers leverage D-glucose-[1,2,4-13C3] in stable isotope labeling experiments to unravel various biochemical processes with precision. This specialized tool facilitates the precise monitoring of glucose-derived metabolites within complex biological systems, shedding light on metabolic pathways, enzyme activities, and regulatory mechanisms. Such in-depth analyses are instrumental in advancing our understanding of biological processes at a molecular level.

Nutritional Research: In the realm of nutritional science, D-glucose-[1,2,4-13C3] serves as a cornerstone for investigating glucose utilization and metabolic impacts in living organisms. By administering labeled glucose, scientists can gauge the efficiency of glucose metabolism and its conversion into energy or storage forms. This research aids in unraveling the intricacies of metabolic health, exploring dietary influences, and deepening our understanding of diabetes pathology, offering valuable insights into public health and therapeutic interventions.