Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-012740 |
Molecular Formula: C6H12O5[18O] |
Molecular Weight: 182.16 |
Chemical Structure |
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Description | D-Fructose-[2-18O] is the labelled analogue of D-Fructose, which is a monosaccharide that naturally occurs in a large number of fruits and plants. |
Synonyms | D-[2-18O]fructose; D-fructose-2-18O; D-(-)-Fructose-2-18O; D-(-)-Levulose-2-18O; D-Arabino-2-hexulose-2-18O; Fructose-2-18O; Furucton-2-18O; Krystar-2-18O; Levulose-2-18O; Nevulose-2-18O |
IUPAC Name | (3S,4R,5R)-2-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol-2-18O |
Related CAS | 57-48-7 (unlabelled) |
Purity | ≥95%; >90% atom 18O |
Solubility | Soluble in Water (Sparingly) |
Appearance | Off-white Solid |
Storage | Store at -20°C |
D-Fructose-[2-18O], a specialized sugar molecule labeled with isotopes, finds diverse applications in biochemical and physiological studies. Here are the key uses of D-Fructose-[2-18O]:
Metabolic Pathway Tracing: In the realm of metabolic research, D-Fructose-[2-18O] plays a pivotal role in tracing the intricate pathways of fructose metabolism within the body. By monitoring the labeled oxygen isotope, researchers unveil the specific enzymatic reactions and metabolic intermediates involved. This detailed analysis sheds light on fructose metabolism and its implications for diseases such as diabetes and obesity, offering invaluable insights into physiological processes.
Enzyme Mechanism Studies: Unveiling the inner workings of enzymes catalyzing fructose-related reactions, D-Fructose-[2-18O] serves as a valuable tool for researchers. By employing this compound, scientists delve into the intricate interactions between enzymes and substrates, discerning the roles of individual oxygen atoms in the catalytic process. Such deep insights aid in designing enzyme modulators for therapeutic interventions, paving the way for targeted treatments in enzyme-related disorders.
Nutritional Research: Delving into the realm of nutritional studies, D-Fructose-[2-18O] facilitates investigations into the processing of fructose within the human body. Through the administration of this labeled compound to study participants, scientists track its absorption, distribution, and conversion into metabolites, unraveling the complexities of dietary fructose metabolism. This knowledge is fundamental for understanding the health implications of fructose consumption, offering a nuanced perspective on dietary impacts on human physiology.
Isotope Labeling in Mass Spectrometry: Positioned at the forefront of mass spectrometry applications, D-Fructose-[2-18O] stands out as a reliable isotopic standard for quantifying fructose levels in complex biological samples. The distinctive 18O label allows for precise detection and measurement of fructose, essential for clinical diagnostics and food analysis where accurate quantification of sugars is paramount. This sophisticated application underscores the importance of precise analytical tools in unraveling the complexities of biological systems.
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