D-Glucose-[2-18O]

D-Glucose-[2-18O], an isotopically labeled form of glucose, finds diverse applications in both scientific and industrial settings. Here are the key applications of D-Glucose-[2-18O]:

Metabolic Tracing: Employing D-Glucose-[2-18O] as a metabolic tracer allows researchers to meticulously track glucose metabolism within living organisms. By monitoring the labeled glucose as it traverses metabolic pathways like glycolysis and the citric acid cycle, valuable insights into metabolic dysregulation in diseases such as diabetes and cancer are gleaned.

Medical Imaging: Within the realm of PET scans, D-Glucose-[2-18O] serves as an invaluable tracer for visualizing and quantifying glucose uptake in tissues. Particularly crucial in oncology, this technique enables the detection and monitoring of tumors, as cancer cells often exhibit heightened glucose uptake. It plays a pivotal role in diagnosing and assessing tumor response to various treatments.

Enzymatic Studies: In the study of enzyme kinetics and mechanisms involved in carbohydrate metabolism, D-Glucose-[2-18O] emerges as a vital tool. By scrutinizing the incorporation of the isotope, researchers gain intricate insights into enzyme-substrate interactions and reaction kinetics. This knowledge is foundational in the development of enzyme inhibitors for potential therapeutic applications.

Agricultural Research: Within the domain of plant biology, D-Glucose-[2-18O] facilitates the investigation of carbohydrate metabolism and transport mechanisms within plants. Through labeling glucose, scientists unravel how plants metabolize sugars and allocate resources under diverse environmental conditions. This research aids in the breeding of crops with enhanced metabolic efficiency and resilience to environmental stressors.