N-acetyl-D-neuraminic acid-[2-13C]

N-acetyl-D-neuraminic acid-[2-13C], a stable isotope-labeled compound, finds primary application in biochemical and medical research. Here are the key applications of N-acetyl-D-neuraminic acid-[2-13C]:

Metabolic Flux Analysis: Researchers leverage N-acetyl-D-neuraminic acid-[2-13C] to trace intricate metabolic pathways within cells and tissues. By integrating this labeled compound into metabolic investigations, scientists can meticulously monitor the assimilation and turnover of neuraminic acid derivatives. This detailed analysis grants profound insights into the dynamic nuances of sialic acid metabolism and its interconnected biosynthetic cascades.

Glycobiology Studies: In the realm of glycobiology, this labeled sialic acid serves as a vital tool for unraveling the mystery of glycoprotein and glycolipid biosynthesis. Through tracking the incorporation of N-acetyl-D-neuraminic acid-[2-13C] into glycan structures, researchers can shed light on the multifaceted roles of sialic acids in cellular recognition signaling and adhesion processes. Understanding these intricate mechanisms is paramount for the development of targeted therapies aimed at combating glycan-mediated diseases.

NMR Spectroscopy: N-acetyl-D-neuraminic acid-[2-13C] emerges as a cornerstone in nuclear magnetic resonance (NMR) spectroscopy for exploring molecular structures and interactions. The strategic 13C labeling elevates the spectral resolution and sensitivity facilitating a nuanced examination of the compound's chemical milieu. This application proves particularly invaluable in the realms of structural biology and drug design research where precise molecular characterization serves as the linchpin for advancements in medical science.

Diagnostic Research: Within the domain of medical diagnostics, N-acetyl-D-neuraminic acid-[2-13C] plays a pivotal role in unraveling metabolic mysteries surrounding sialic acid pathways. Through scrutinizing the metabolic journey of this labeled compound in bodily fluids or tissues, experts can diagnose and monitor conditions like sialuria and sialidosis. This diagnostic approach not only aids in the identification of biomarkers but also lays the groundwork for developing targeted therapeutic interventions for these rare and enigmatic diseases.