N-acetyl-D-neuraminic acid-[1-13C]

N-acetyl-D-neuraminic acid-[1-13C], a stable isotope-labeled compound, plays a pivotal role in metabolic and biomedical research. Here are the key applications of N-acetyl-D-neuraminic acid-[1-13C]:

Metabolic Tracing Studies: Delving into the intricate world of metabolic pathways, N-acetyl-D-neuraminic acid-[1-13C] serves as a beacon for researchers in metabolic tracing studies. By intricately weaving the labeled compound into cellular systems, scientists embark on a journey to unravel the intricate web of biosynthesis and degradation pathways of sialic acids. Through the lens of mass spectrometry, researchers can track the compound's incorporation and metamorphosis within metabolic networks, shedding light on the enigmatic destiny of sialic acids in diverse physiological and pathological states.

Glycobiology Research: Unveiling the mysteries of glycobiology, N-acetyl-D-neuraminic acid-[1-13C] emerges as a key player in the study of sialylation processes within glycoproteins and glycolipids. The labeled sialic acid acts as a portal, offering insights into the dynamic world of glycan structures adorning cell surfaces and secreted molecules. This knowledge serves as a cornerstone for deciphering the cryptic language of cell-cell interactions, immune recognition, and pathogen binding, unveiling the hidden complexities of cellular communication.

MRI Contrast Agents: Aiming to revolutionize diagnostic imaging, N-acetyl-D-neuraminic acid-[1-13C] takes center stage in the development of cutting-edge MRI contrast agents. When integrated into the fabric of contrast agent molecules, the labeled sialic acid becomes a beacon of clarity, enhancing their efficacy in illuminating specific tissues and pathological regions. This pioneering innovation holds the key to advancing diagnostic imaging in the realms of oncology and neurological disorders, offering a newfound perspective on disease detection and characterization.

Structural Biology: Embarking on a quest to unravel the intricacies of enzyme mechanisms and protein interactions, the labeled N-acetyl-D-neuraminic acid-[1-13C] emerges as a critical tool in the realm of structural biology. Through the lens of NMR spectroscopy and other analytical marvels, this compound unravels the intricate dance between enzymes and sialic acid-binding proteins, offering a detailed glimpse into binding sites and conformational changes upon interaction. This profound knowledge serves as a guiding light in the design of inhibitors and therapeutic agents targeting pathways intertwined with sialic acid, paving the way for innovative therapeutic interventions.